Article

Biological Trace Element Research

, Volume 143, Issue 3, pp 1651-1665

First online:

The Protective Effects of Tea Polyphenols and Schisandrin B on Nephrotoxicity of Mercury

  • Wei LiuAffiliated withDepartment of Environmental Health, School of Public Health, China Medical University
  • , Zhaofa XuAffiliated withDepartment of Environmental Health, School of Public Health, China Medical University Email author 
  • , Haibo YangAffiliated withDepartment of Environmental Health, School of Public Health, China Medical University
  • , Yu DengAffiliated withDepartment of Environmental Health, School of Public Health, China Medical University
  • , Bin XuAffiliated withDepartment of Environmental Health, School of Public Health, China Medical University
  • , Yangang WeiAffiliated withDepartment of Environmental Health, School of Public Health, China Medical University

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Abstract

Mercury (Hg) is an occupational and environmental contaminant that is a well-recognized health hazard. To approach the concrete mechanisms of mercury nephrotoxicity and find out a new way to prevent it, the rats were subcutaneously injected with different dosages of mercuric chloride (HgCl2)—0, 2.2, 4.4, and 8.8 μmol/kg. The levels of Hg, blood urea nitrogen (BUN), urine protein, glutathione (GSH), malondialdehyde (MDA) and activities of N-acetyl-beta-d-glucosaminidase (NAG), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were investigated, and the levels of reactive oxygen species (ROS) and apoptosis and the pathological changes were also observed. In addition, the effects of 1 mmol/kg tea polyphenols (TP) and 0.04 mmol/kg schisandrin B (Sch B) were studied at 8.8 μmol/kg HgCl2. It was observed that the levels of Hg, BUN, urine protein, GSH, and MDA and activities of NAG, ALP, and LDH increased significantly; the activities of SOD and GSH-Px decreased significantly; the levels of ROS and apoptosis increased obviously; and many pathological changes occurred dose-dependently in the HgCl2 injection groups. Further investigation indicated that pretreatment with TP and Sch B significantly reversed the toxic effects of HgCl2. These results suggested that TP and Sch B might antagonize the nephrotoxicity caused by HgCl2 exposure.

Keywords

Mercury Nephrotoxicity Oxidative damage Tea polyphenols Schisandrin B