Biological Trace Element Research

, Volume 143, Issue 3, pp 1289–1301

Continuous Positive Airway Pressure Therapy Reduces Oxidative Stress Markers and Blood Pressure in Sleep Apnea–Hypopnea Syndrome Patients

  • Mora Murri
  • Regina García-Delgado
  • José Alcázar-Ramírez
  • Luis Fernández de Rota
  • Ana Fernández-Ramos
  • Fernando Cardona
  • Francisco J. Tinahones
Article

DOI: 10.1007/s12011-011-8969-1

Cite this article as:
Murri, M., García-Delgado, R., Alcázar-Ramírez, J. et al. Biol Trace Elem Res (2011) 143: 1289. doi:10.1007/s12011-011-8969-1

Abstract

Sleep apnea–hypopnea syndrome (SAHS) is characterized by recurrent episodes of hypoxia/reoxygenation, which seems to promote oxidative stress. SAHS patients experience increases in hypertension, obesity and insulin resistance (IR). The purpose was to evaluate in SAHS patients the effects of 1 month of treatment with continuous positive airway pressure (CPAP) on oxidative stress and the association between oxidative stress and insulin resistance and blood pressure (BP). Twenty-six SAHS patients requiring CPAP were enrolled. Measurements were recorded before and 1 month after treatment. Cellular oxidative stress parameters were notably decreased after CPAP. Intracellular glutathione and mitochondrial membrane potential increased significantly. Also, total antioxidant capacity and most of the plasma antioxidant activities increased significantly. Significant decreases were seen in BP. Negative correlations were observed between SAHS severity and markers of protection against oxidative stress. BP correlated with oxidative stress markers. In conclusion, we observed an obvious improvement in oxidative stress and found that it was accompanied by an evident decrease in BP with no modification in IR. Consequently, we believe that the decrease in oxidative stress after 1 month of CPAP treatment in these patients is not contributing much to IR genesis, though it could be related to the hypertension etiology.

Keywords

Continuous positive airway pressureHypertensionInsulin resistanceOxidative stressSleep apnea–hypopnea syndrome

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Mora Murri
    • 1
  • Regina García-Delgado
    • 2
  • José Alcázar-Ramírez
    • 3
  • Luis Fernández de Rota
    • 3
  • Ana Fernández-Ramos
    • 2
  • Fernando Cardona
    • 1
    • 4
  • Francisco J. Tinahones
    • 4
    • 5
  1. 1.Laboratorio de Investigaciones Biomédicas, Fundación IMABISHospital Clínico Universitario Virgen de la VictoriaMálagaSpain
  2. 2.Servicio de HematologíaHospital Clínico Universitario Virgen de la VictoriaMálagaSpain
  3. 3.Servicio de NeumologíaHospital Clínico Universitario Virgen de la VictoriaMálagaSpain
  4. 4.Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBER CB06/003)Instituto de Salud Carlos IIIMálagaSpain
  5. 5.Servicio de Endocrinología y NutriciónHospital Clínico Universitario Virgen de la VictoriaMálagaSpain