Biological Trace Element Research

, Volume 143, Issue 2, pp 835–843

Intra-erythrocyte Magnesium Is Associated with Gamma-Glutamyl Transferase in Obese Children and Adolescents

  • Maryam Tohidi
  • Asghar Ghasemi
  • Farzad Hadaegh
  • Shamsi Arbabi
  • Firoozeh Hosseini Isfahani
Article

DOI: 10.1007/s12011-010-8949-x

Cite this article as:
Tohidi, M., Ghasemi, A., Hadaegh, F. et al. Biol Trace Elem Res (2011) 143: 835. doi:10.1007/s12011-010-8949-x
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Abstract

This study aims at determining the association between markers of hepatic injury and serum, urinary, and intra-erythrocyte magnesium concentrations and dietary magnesium intake in obese children and adolescents. In a case–control study, 42 obese children and adolescents (8–18 years) and 42 sex- and puberty-matched controls were studied. Serum, urinary, and intra-erythrocyte magnesium levels, indices of insulin sensitivity, and liver enzymes were measured. Dietary magnesium intake was assessed using a food frequency questionnaire. Obese children and adolescents exhibited insulin resistance as determined by a higher fasting insulin and the HOMA-IR (p < 0.001) and lower QUICKI indices (p = 0.001); in addition these subjects had significantly higher intra-erythrocyte magnesium (IEM) concentrations, than non-obese ones (3.99 ± 1.05 vs. 3.35 ± 1.26 mg/dL of packed cell; p = 0.015). Among liver enzymes, only gamma-glutamyl transferase (GGT) was significantly higher in obese than in non-obese subjects (22.7 ± 9.4 vs. 17.1 ± 7.9 U/l; p = 0.002). A positive association was found between GGT and IEM in both groups; however in multivariate analysis, in obese subjects, only GGT (p = 0.026) and, in non-obese subjects, only age (p = 0.006) remained as significant predictors of IEM. In conclusion, increased IEM concentration was seen in insulin-resistant obese children and adolescents; furthermore, serum GGT was associated with IEM, independently of body mass index and HOMA-IR.

Keywords

AdolescentChildrenGamma-glutamyl transferaseMagnesiumObesity

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Maryam Tohidi
    • 1
  • Asghar Ghasemi
    • 2
  • Farzad Hadaegh
    • 1
  • Shamsi Arbabi
    • 1
  • Firoozeh Hosseini Isfahani
    • 3
  1. 1.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Endocrine Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Obesity Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran