Biological Trace Element Research

, Volume 141, Issue 1, pp 110–118

Supplemental Selenium Alleviates the Toxic Effects of Excessive Iodine on Thyroid

  • Jian Xu
  • Xiao-Li Liu
  • Xue-Feng Yang
  • Huai-Lan Guo
  • Li-na Zhao
  • Xiu-Fa Sun
Article

DOI: 10.1007/s12011-010-8728-8

Cite this article as:
Xu, J., Liu, XL., Yang, XF. et al. Biol Trace Elem Res (2011) 141: 110. doi:10.1007/s12011-010-8728-8

Abstract

As excessive iodine intake is associated with a decrease of the activities of selenocysteine-containing enzymes, supplemental selenium was hypothesized to alleviate the toxic effects of excessive iodine. In order to verify this hypothesis, Balb/C mice were tested by giving tap water with or without potassium iodate and/or sodium selenite for 16 weeks, and the levels of iodine in urine and thyroid, the hepatic selenium level, the activities of glutathione peroxidase (GSHPx), type 1 deiodinase (D1), and thyroid peroxidase (TPO) were assayed. It had been observed in excessive iodine group that hepatic selenium, the activities of GSHPx, D1, and TPO decreased, while in the groups of 0.2 mg/L, 0.3 mg/L and 0.4 mg/L supplemental selenium, the urinary iodine increased significantly. Compared with the group of excessive iodine intake alone, supplemental selenium groups had higher activities of GSHPx, D1, and TPO. We could draw the conclusion that supplemental selenium could alleviate toxic effect of excessive iodine on thyroid. The optimal dosage of selenium ranges from 0.2 to 0.3 mg/L which can protect against thyroid hormone dysfunction induced by excessive iodine intake.

Keywords

Selenium Iodine Type 1 deiodinase Glutathione peroxidase Thyroid peroxidase Mouse 

Abbreviations

GSHPx

glutathione peroxidase

TPO

thyroid peroxidase

D1

type 1 deiodinase

H2O2

hydrogen peroxide

NI

normal controls

EI

excessive iodine group

IS groups

selenium groups

T4

thyroxine

T3

triiodothyronine

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jian Xu
    • 1
  • Xiao-Li Liu
    • 1
  • Xue-Feng Yang
    • 2
  • Huai-Lan Guo
    • 2
  • Li-na Zhao
    • 2
  • Xiu-Fa Sun
    • 2
  1. 1.Shenzhen Center for Chronic Disease ControlShenzhenPeople’s Republic of China
  2. 2.Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China

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