Article

Biological Trace Element Research

, Volume 140, Issue 3, pp 330-341

Testicular Histomorphometry and Ultrastructure of Rats Treated with Cadmium and Ginkgo biloba

  • Fabrícia de Souza PredesAffiliated withRua Charles Darwin, s/n, Department of Anatomy, Cellular Biology, Physiology and Biophysics, State University of CampinasDepartamento de Anatomia, Biologia Celular e Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas-UNICAMP Email author 
  • , Juliana Castro MonteiroAffiliated withRua Charles Darwin, s/n, Department of Anatomy, Cellular Biology, Physiology and Biophysics, State University of Campinas
  • , Sérgio Luis Pinto MattaAffiliated withDepartment of General Biology, Federal University of Viçosa
  • , Márcia C. GarciaAffiliated withRua Charles Darwin, s/n, Department of Anatomy, Cellular Biology, Physiology and Biophysics, State University of Campinas
  • , Heidi DolderAffiliated withRua Charles Darwin, s/n, Department of Anatomy, Cellular Biology, Physiology and Biophysics, State University of Campinas

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Abstract

The aim of this study is to investigate the association of a single low dose of Cd and daily doses of Ginkgo biloba extract (GbE) on the testis and accessory glands of rats. The animals were treated with a single dose of 3 µmol/kg body weight of cadmium chloride (CdCl2) and/or 100 mg/kg body weight of GbE. The plasma testosterone levels; corporal, testicular, and accessory glands weight; gonadosomatic index, volumetric proportion; and absolute volume of testicular components did not change after the treatments. CdCl2 caused significant reduction in Leydig cells volume and altered Leydig cell morphology, as well as vacuolated Sertoli cells cytoplasm, irregular chromatin condensation of late spermatids, and modified acrosome formation. However, animals that received GbE did not show these alterations. The reversal of Cd-induced alterations by the extract is a strong indication that G. biloba is helpful in diminishing the effect of Cd toxicity.

Keywords

Wistar rat Ginkgo biloba Cadmium Morphometry and ultrastructure