Biological Trace Element Research

, Volume 137, Issue 3, pp 335–339

Diminished Selenium Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

  • Maryam Pakfetrat
  • Leila Malekmakan
  • Mahshid Hasheminasab
Article

DOI: 10.1007/s12011-009-8588-2

Cite this article as:
Pakfetrat, M., Malekmakan, L. & Hasheminasab, M. Biol Trace Elem Res (2010) 137: 335. doi:10.1007/s12011-009-8588-2

Abstract

In this cross-sectional study, selenium (Se) levels in the sera of 35 hemodialysis (HD) patients and 34 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) for more than 3 months were compared with the serum Se levels of 34 healthy volunteers. The observed Se levels of 100.8 ± 51.9 µg/L in the sera of the HD patients and of 65.5 ± 32.1 µg/L in the sera of the CAPD patients were significantly lower than the 134.9 ± 81.2 µg/L of the controls, with p = 0.002 and 0.02, respectively. Furthermore, the Se levels were significantly higher in the HD rather than the CAPD patients (p = 0.01). In the spent dialysate effluent fluid of 32 of the CAPD patients Se was undetectable, in the remaining two CAPD patients the Se levels were 1.9 and 4.6μg/l, respectively. The low Se levels of HD and CAPD patients as compared to healthy persons are attributed to diminished Se retention due to chronic oxidative stress.

Keywords

HemodialysisPeritoneal dialysisSelenium

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Maryam Pakfetrat
    • 1
  • Leila Malekmakan
    • 1
  • Mahshid Hasheminasab
    • 1
  1. 1.Shiraz Nephro-Urology Research CenterShiraz University of Medical SciencesShirazIran