Relative and Combined Effects of Chronic Alcohol Consumption and HCV Infection on Serum Zinc, Copper, and Selenium

  • Emilio González-Reimers
  • M. Candelaria Martín-González
  • M. Remedios Alemán-Valls
  • María José de la Vega-Prieto
  • Luis Galindo-Martín
  • Pedro Abreu-González
  • Francisco Santolaria-Fernández
Article

DOI: 10.1007/s12011-009-8399-5

Cite this article as:
González-Reimers, E., Martín-González, M.C., Alemán-Valls, M.R. et al. Biol Trace Elem Res (2009) 132: 75. doi:10.1007/s12011-009-8399-5

Abstract

In alcoholic hepatitis, Kupffer cells are activated by intestinal gram-bacteria, leading to cytokine production and free radicals release, which, enhancing cytokine secretion, create a positive feedback loop which contributes to liver inflammation. Free radicals also damage the liver in chronic hepatitis C virus (HCV) infection, a condition frequently associated to alcohol consumption. In both situations, activity of antioxidant enzymes and of its cofactors zinc (Zn), selenium (Se), and copper (Cu) is important. This study was performed to assess the relative and combined effects of chronic alcoholism and HCV infection on serum Se, Zn, and Cu, and its relation with serum malondialdehyde (MDA) and tumor necrosis factor-α, interferon-γ, and interleukins (IL) 4, 6, and 8, in 19 HCV− alcoholic patients, 12 HCV+ alcoholic patients, nine HCV+ non-alcoholic patients, and 20 controls. Serum Zn and Se were lower in both HCV+ and HCV− alcoholic patients, whereas serum Cu was lower in HCV+ individuals. Serum Zn and Se were related to liver function derangement. MDA levels were higher in alcoholics, but no relation was observed between trace elements and MDA or cytokines, so that our results do not support a relevant role of the analyzed trace elements in the pathogenesis of chronic liver disease.

Keywords

Alcoholic hepatitis HCV infection Lipid peroxidation Zinc Selenium Copper 

Abbreviations

BMI

Body mass index

ELISA

Enzyme-linked immunosorbent assay

GPX

Glutathione peroxidase

HCV

Hepatitis C virus

IFN

Interferon

IL

Interleukin

MDA

Malondialdehyde

NADP

Nicotine adenine dinucleotide phosphate

NADH

Reduced nicotine adenine dinucleotide phosphate

SOD

Superoxide dismutase

TBA

Thiobarbituric acid

TBARS

Thiobarbituric acid-reactive substance

TNF

Tumor necrosis factor

Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Emilio González-Reimers
    • 1
  • M. Candelaria Martín-González
    • 1
  • M. Remedios Alemán-Valls
    • 1
  • María José de la Vega-Prieto
    • 2
  • Luis Galindo-Martín
    • 3
  • Pedro Abreu-González
    • 4
  • Francisco Santolaria-Fernández
    • 1
  1. 1.Servicio de Medicina InternaHospital Universitario, Universidad de La LagunaTenerifeSpain
  2. 2.Servicio de LaboratorioHospital Universitario, Universidad de La LagunaTenerifeSpain
  3. 3.Dpto. de Química Analítica, Facultad de QuímicaUniversidad de La LagunaTenerifeSpain
  4. 4.Dpto de Fisiología, Facultad de MedicinaUniversidad de La LagunaTenerifeSpain

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