Article

Biological Trace Element Research

, Volume 121, Issue 2, pp 160-170

First online:

Experimental Study on the Estrogen-Like Effect of Boric Acid

  • Yadong WangAffiliated withDepartment of Toxicology, Zhengzhou University of HenanHenan Center for Disease Control and Prevention
  • , Yingzheng ZhaoAffiliated withDepartment of Toxicology, Zhengzhou University of Henan
  • , Xiaoyu ChenAffiliated withDepartment of Toxicology, Zhengzhou University of Henan Email author 

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Abstract

There are now considerable evidences that boric acid has reproductive and developmental toxicity, but it is uncertain whether such toxicity is caused by estrogen-like effect. Our objective is to determine the estrogen-like effect of boric acid. Proliferation assay of MCF-7 human breast cancer cells, uterotrophic assay, measure assay of the estradiol (E2), proliferation assay of mucous membrane cells, and assay of estrogen receptor were conducted in this study. Boric acid could increase the weight of uterus of ovariectomized SD rats and the height of epithelium cells of mucous membrane, enhance the expression of the proliferating cell nucleus antigen, and reduce the density of estrogen receptors. However, boric acid could not affect the level of estradiol in serum and stimulate the proliferation of MCF-7 human breast cancer cells. In this study, boric acid exhibited the estrogen-like effect in vivo.

Keywords

Boric acid Proliferation assay of MCF-7 human breast cancer cells Uterotrophic assay Proliferation assay in mucous membrane Estrogen receptor (ER)