Sox9 Is Upstream of MicroRNA-140 in Cartilage
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- Nakamura, Y., He, X., Kato, H. et al. Appl Biochem Biotechnol (2012) 166: 64. doi:10.1007/s12010-011-9404-y
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MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet-derived growth factor receptor alpha (pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant (sox9a−/−) and sox9b mutant (sox9b−/−) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells.