Clinical Orthopaedics and Related Research®

, Volume 470, Issue 7, pp 1895–1906

Pseudotumors Are Common in Well-positioned Low-wearing Metal-on-Metal Hips

  • Ashley K. Matthies
  • John A. Skinner
  • Humza Osmani
  • Johann Henckel
  • Alister J. Hart
Symposium: Retrieval Studies

DOI: 10.1007/s11999-011-2201-7

Cite this article as:
Matthies, A.K., Skinner, J.A., Osmani, H. et al. Clin Orthop Relat Res (2012) 470: 1895. doi:10.1007/s11999-011-2201-7

Abstract

Background

Pseudotumors are sterile inflammatory lesions found in the soft tissues surrounding metal-on-metal (MOM) and metal-on-polyethylene hip arthroplasties. In patients with MOM hip arthroplasties, pseudotumors are thought to represent an adverse reaction to metal wear debris. However, the pathogenesis of these lesions remains unclear. Currently, there is inconsistent evidence regarding the influence of adverse cup position and increased wear in the formation of pseudotumors.

Questions/purposes

We therefore determined whether pseudotumor formation was associated with (1) adverse cup position, (2) raised metal ion levels, and (3) increased wear rates of the retrieved components.

Methods

We retrospectively reviewed all 352 patients for whom we had retrieved specimens from revisions of a current-generation MOM hip prosthesis between February 2008 and September 2010; of these, 105 met our inclusion criteria. We used multivariate logistic regression analysis to compare acetabular orientation, metal ion levels before revision, and component wear rates between patients with (n = 72) and without (n = 33) pseudotumors, according to findings on metal artifact reduction sequence MRI.

Results

The proportion of patients demonstrating evidence of a pseudotumor in well-positioned hips was similar to those with adverse cup positions (67% and 66%, respectively). Patients revised with pseudotumors had similar whole-blood metal ion levels and component wear rates to those who were not revised.

Conclusions

Pseudotumors were not associated with increased wear or metal ion levels, suggesting patient susceptibility is likely to be more important.

Copyright information

© The Association of Bone and Joint Surgeons® 2011

Authors and Affiliations

  • Ashley K. Matthies
    • 1
  • John A. Skinner
    • 2
  • Humza Osmani
    • 1
  • Johann Henckel
    • 1
  • Alister J. Hart
    • 1
  1. 1.Department of Musculoskeletal SurgeryImperial College LondonLondonUK
  2. 2.Department of Orthopedic SurgeryRoyal National Orthopaedic HospitalStanmoreUK

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