Clinical Orthopaedics and Related Research®

, Volume 468, Issue 9, pp 2430–2436

Natural Course of Asymptomatic Deep Venous Thrombosis in Hip Surgery without Pharmacologic Thromboprophylaxis in an Asian Population

  • Kosuke Tsuda
  • Tomio Kawasaki
  • Nobuo Nakamura
  • Hideki Yoshikawa
  • Nobuhiko Sugano
Clinical Research

DOI: 10.1007/s11999-009-1220-0

Cite this article as:
Tsuda, K., Kawasaki, T., Nakamura, N. et al. Clin Orthop Relat Res (2010) 468: 2430. doi:10.1007/s11999-009-1220-0



The clinical importance of asymptomatic deep venous thrombosis in elective hip surgery is not clearly known.


We determined the preoperative and postoperative incidences of asymptomatic deep venous thrombosis, identified preoperative factors associated with postoperative deep venous thrombosis or pulmonary embolism, and established its natural course in patients who underwent elective hip surgery without receiving pharmacologic thromboprophylaxis.

Patients and Methods

We reviewed 184 patients who underwent consecutive elective hip surgeries with a mechanical thromboprophylaxis regimen including combined general and epidural anesthesia, intraoperative calf bandaging, early mobilization, and postoperative intermittent pneumatic compression with additional use of elastic stockings. Duplex ultrasonography was performed routinely to diagnose deep venous thrombosis in all patients before surgery and on Postoperative Days 3 and 21. All patients with postoperative deep venous thrombosis underwent additional ultrasonography at 3-month intervals, and all patients were followed postoperatively for 6 months or more.


Preoperatively, we found asymptomatic deep venous thrombosis in two patients (1%); both thromboses had completely and spontaneously resolved by Postoperative Day 21. Postoperatively, no patients had a fatal or symptomatic pulmonary embolism or proximal deep venous thrombosis, but nine patients (5%) had asymptomatic distal deep venous thrombosis develop, with no preoperative associated factors. These nine patients were followed closely without anticoagulant drugs, and all thromboses had disappeared without pulmonary embolism or thrombophlebitis by 6 months.


The incidence of preoperative and postoperative deep venous thrombosis was low in an Asian population having elective hip surgery and a nonpharmacologic thromboprophylaxis regimen. There were no preoperative factors associated with postoperative deep venous thrombosis, and all asymptomatic deep venous thromboses resolved spontaneously without associated pulmonary embolism or thrombophlebitis.

Level of Evidence

Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

Copyright information

© The Association of Bone and Joint Surgeons® 2010

Authors and Affiliations

  • Kosuke Tsuda
    • 1
  • Tomio Kawasaki
    • 2
  • Nobuo Nakamura
    • 3
  • Hideki Yoshikawa
    • 1
  • Nobuhiko Sugano
    • 4
  1. 1.Department of Orthopaedic SurgeryOsaka University Graduate School of MedicineSuita, OsakaJapan
  2. 2.Department of Cardiovascular SurgeryOsaka University Graduate School of MedicineSuitaJapan
  3. 3.Center of ArthroplastyKyowakai HospitalSuitaJapan
  4. 4.Department of Orthopaedic Medical EngineeringOsaka University Graduate School of MedicineSuitaJapan

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