Current Treatment Options in Neurology

, 16:301

Management of Pediatric Status Epilepticus

Pediatric Neurology (HS Singer, Section Editor)

DOI: 10.1007/s11940-014-0301-x

Cite this article as:
Abend, N.S. & Loddenkemper, T. Curr Treat Options Neurol (2014) 16: 301. doi:10.1007/s11940-014-0301-x
Part of the following topical collections:
  1. Topical Collection on Pediatric Neurology

Opinion statement

Status epilepticus (SE) is a medical emergency consisting of persistent or recurring seizures without a return to baseline mental status. SE can be divided into subtypes based on seizure types and underlying etiologies. Management should be implemented rapidly and based on pre-determined care pathways. The aim is to terminate seizures while simultaneously identifying and managing precipitant conditions. Seizure management involves “emergent” treatment with benzodiazepines (lorazepam intravenously, midazolam intramuscularly, or diazepam rectally) followed by “urgent” therapy (phenytoin/fosphenytoin, phenobarbital, levetiracetam or valproate sodium). If seizures persist, “refractory” treatments include infusions of midazolam or pentobarbital. Prognosis is dependent on the underlying etiology and seizure persistence. This article reviews the current management strategies for pediatric convulsive SE.


Status epilepticusSESeizurePediatricManagement

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Departments of Neurology and PediatricsThe Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Division of Epilepsy and Clinical Neurophysiology, Department of NeurologyBoston Children’s Hospital and Harvard Medical SchoolBostonUSA