Current Treatment Options in Neurology

, Volume 14, Issue 2, pp 137–149

Therapeutics in Huntington’s Disease

Cognitive Disorders (M Geschwind, Section Editor)

DOI: 10.1007/s11940-012-0165-x

Cite this article as:
Killoran, A. & Biglan, K.M. Curr Treat Options Neurol (2012) 14: 137. doi:10.1007/s11940-012-0165-x

Opinion statement

There is no specific treatment for Huntington’s disease (HD). Its many symptoms of motor, psychiatric, and cognitive deterioration are managed with symptomatic relief, rehabilitation, and support. The only drug approved by the US Food and Drug Administration (FDA) for the treatment of HD is an antichoreic agent, tetrabenazine, but this drug is used sparingly because of uneasiness regarding its propensity to cause depression and suicidality in this population, which is already at risk for these complications. Neuroleptics are still first-line treatments for chorea accompanied by comorbid depression and/or behavioral or psychotic symptoms, as is often the case. Psychiatric features, which have a significant impact on a patient’s professional and personal life, often become the major focus of management. In addition to neuroleptics, commonly used medications include antidepressants, mood stabilizers, anxiolytics, and psychostimulants. In contrast, few treatment options are available for cognitive impairment in HD; this remains an important and largely unmet therapeutic need. HD patients typically lack insight into their disease manifestations, failing to recognize their need for treatment, and possibly even arguing against it. Multipurpose medications are employed advantageously to simplify the medication regimen, so as to facilitate compliance and not overwhelm the patient. For example, haloperidol can be prescribed for a patient with chorea, agitation, and anorexia, rather than targeting each symptom with a different drug. This approach also limits the potential for adverse effects, which can be difficult to distinguish from the features of the disease itself. With HD’s complexity, it is best managed with a multidisciplinary approach that includes a movement disorders specialist, a genetic counselor, a mental health professional, a physical therapist, and a social worker for support and coordination of services. As the disease progresses, there may be need for other specialists, such as a speech and occupational therapist, a nutritionist for weight loss, and ultimately, a palliative care specialist.


Huntington’s disease Huntington disease Chorea Treatment Therapy Tetrabenazine Neuroleptics Haloperidol Juvenile Huntington’s disease Pharmacologic treatment Trinucleotide repeat disorder 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Experimental Therapeutics in Movement DisordersUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Movement and Inherited Neurological Disorders Unit in the Department of NeurologyUniversity of Rochester School of Medicine and DentistryRochesterUSA

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