Levine M, Gent M, Hirsh J, et al.
: A comparison of lowmolecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis
. N Engl J Med
:677–681. In this study, 500 patients with acute proximal deep vein thrombosis were randomly assigned to receive either intravenous unfractionated heparin in the hospital or low-molecular-weight heparin (LMWH, twice-daily subcutaneous enoxaparin in a dose of 1 mg/kg) administered primarily at home. Recurrent venous thromboembolism developed in 5.3% of patients administered LMWH compared with 6.7% of those administered unfractionated heparin (P
= 0.57). Major bleeding occurred in five patients given LMWH and in three patients randomized to receive unfractionated heparin. Patients administered LMWH spent a mean of 1.1 days in the hospital, compared with 6.5 days for those administered unfractionated heparin.PubMedCrossRefGoogle Scholar