Current Treatment Options in Cardiovascular Medicine

, Volume 15, Issue 3, pp 360–371

PFO Closure for Cryptogenic Stroke: Review of New Data and Results

Cerebrovascular Disease and Stroke (C Helgason and M Alberts, Section Editors)

DOI: 10.1007/s11936-013-0243-8

Cite this article as:
Rao, S. & Sila, C. Curr Treat Options Cardio Med (2013) 15: 360. doi:10.1007/s11936-013-0243-8

Opinion statement

Observational studies over 20 years have suggested that a patent foramen ovale (PFO) is an important cause of cryptogenic stroke in young individuals; case series and registries suggest that PFO closure confers superior protection from recurrent transient ischemic attack (TIA) and stroke. Recently completed randomized clinical trials did not confirm this hypothesis, but have provided reassurance that the risk of recurrent stroke is low at 1.5 %/yr. A target subset that may benefit are those with ischemic stroke, a large right-to-left shunt, and an atrial septal aneurysm. Further study is needed to determine the optimum strategy to reduce the long-term stroke risk in a lifetime of varying situational risk factors and temporary interruptions of medical therapies.

Keywords

Patent foramen ovalePFO occlude deviceAtrial septal aneurysmCryptogenic strokeStroke of undetermined causeAtrial fibrillation

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Internal MedicineFairview HospitalClevelandUSA
  2. 2.Comprehensive Stroke CenterUniversity Hospitals - Case Medical CenterClevelandUSA
  3. 3.Department NeurologyCase Western Reserve School of MedicineClevelandUSA