Current Urology Reports

, Volume 14, Issue 5, pp 448–456

From Physiology to Pharmacy: Developments in the Pathogenesis and Treatment of Recurrent Urinary Tract Infections

  • Jennifer A. Silverman
  • Henry L. SchreiberIV
  • Thomas M. Hooton
  • Scott J. Hultgren
Lower Urinary Tract Symptoms and Voiding Dysfunction (G Badlani and H Goldman, Section Editors)

DOI: 10.1007/s11934-013-0354-5

Cite this article as:
Silverman, J.A., Schreiber, H.L., Hooton, T.M. et al. Curr Urol Rep (2013) 14: 448. doi:10.1007/s11934-013-0354-5

Abstract

Urinary tract infections (UTIs) are common, and over half of women report having had at least one in their lifetime. Nearly a third of these women experience recurrent UTI episodes, but the mechanisms of these recurrences are not fully elucidated. Frequent use of antimicrobials for treatment and prevention of UTIs and other infections has contributed to the evolution of multidrug-resistant microorganisms globally. This is a looming worldwide crisis that has created an urgent need for novel strategies for the treatment and prevention of UTIs. Furthering our understanding of the mechanisms of recurrent UTIs, from both host and bacterial perspectives, will be paramount in developing targeted management strategies. In this review, we discuss recent findings regarding recurrent UTIs in women, including progress in our understanding of the mechanisms of recurrence as well as emerging treatments.

Keywords

Recurrent urinary tract infection Antibiotic resistance Mannoside Pilicide FimH Stress response 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jennifer A. Silverman
    • 1
  • Henry L. SchreiberIV
    • 1
  • Thomas M. Hooton
    • 2
  • Scott J. Hultgren
    • 1
  1. 1.Department of Molecular Microbiology and Microbial Pathogenesis; Center for Women’s Infectious Disease ResearchWashington University School of MedicineSaint LouisUSA
  2. 2.Department of MedicineUniversity of Miami Miller School of MedicineMiamiUSA