Current Urology Reports

, Volume 13, Issue 2, pp 147–152

Recent Advances in Treatment of Advanced Urothelial Carcinoma

Bladder and Urothelial Cancer (A Sagalowsky, Section Editor)

DOI: 10.1007/s11934-012-0238-0

Cite this article as:
Kim, J.J. Curr Urol Rep (2012) 13: 147. doi:10.1007/s11934-012-0238-0


GC (cisplatin and gemcitabine) and MVAC (methotrexate, vinblastine, Adriamycin [doxorubicin], and cisplatin) have been the standard systemic chemotherapy in advanced urothelial carcinoma. These regimens have shown significant response rates in this patient population. Nevertheless, disease does recur with most patients who unfortunately do succumb to the disease. Research efforts are focused in several different areas of therapy, targeted therapy, and immunotherapy. Further efforts include those in improving understanding of the molecular biology of urothelial carcinoma which may lead development of biomarkers that may enhance therapeutic index. This paper reviews recent advances in the treatment and ongoing study of molecular biology of urothelial carcinoma.


Urothelial carcinomaChemotherapyTargeted therapyImmunotherapyBiomarker

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimoreUSA