Current Urology Reports

, 12:336

Stem Cell Therapy for Incontinence: Where Are We Now? What is the Realistic Potential?

  • Charuspong Dissaranan
  • Michelle A. Cruz
  • Bruna M. Couri
  • Howard B. Goldman
  • Margot S. Damaser
Article

DOI: 10.1007/s11934-011-0210-4

Cite this article as:
Dissaranan, C., Cruz, M.A., Couri, B.M. et al. Curr Urol Rep (2011) 12: 336. doi:10.1007/s11934-011-0210-4

Abstract

A significant number of women experience stress urinary incontinence (SUI), which greatly affects their quality of life. Recent research investigating utilization of stem cells and their derivatives for the prevention and treatment of SUI has been performed to test the effect of cell source and method of administration in several animal models of SUI. The type of stem cell, timing of optimal dose or doses after injury, mechanism of action of stem cells, and route of administration must be investigated both preclinically and clinically before stem cell therapy becomes a possible treatment for SUI, although the future of this therapy looks promising. This article reviews the progress in stem cell research for incontinence and describes areas of future work as suggested by research in other fields.

Keywords

Stem cellIncontinenceRegenerativeVoiding dysfunctionStress urinary incontinenceWomen’s healthGynecologyNoninvasive therapyMuscle-derived stem cellsMDSCsBone marrow–derived stem cellsBMSCsAdipose-derived stem cellsADCSCsHuman umbilical-cord blood cellsHUCBs

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2011

Authors and Affiliations

  • Charuspong Dissaranan
    • 1
  • Michelle A. Cruz
    • 1
    • 2
  • Bruna M. Couri
    • 3
  • Howard B. Goldman
    • 1
  • Margot S. Damaser
    • 1
    • 2
    • 4
  1. 1.Glickman Urological and Kidney Institute, Cleveland ClinicClevelandUSA
  2. 2.Department of Biomedical EngineeringCleveland ClinicClevelandUSA
  3. 3.Department of Obstetrics and GynecologyCleveland ClinicClevelandUSA
  4. 4.Louis Stokes Cleveland Department of Veterans Administration Medical CenterAdvanced Platform Technology CenterClevelandUSA