Androgen Suppression Strategies for Prostate Cancer: Is There an Ideal Approach?
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Androgen suppression therapy (AST) was first described in 1941 as a treatment of prostate cancer (PCa) and remains the mainstay of therapy in patients with hormone-naïve metastatic disease. It also is used in locally advanced or recurrent disease and in combination with radiation therapy in patients with higher-risk features. Several approaches to AST have been developed as a result of increased understanding of the pathways controlling testosterone production. Increased recognition of the side effects has resulted in strategies to minimize complications associated with AST. Attempts to reduce AST adverse effects include intermittent hormonal therapy and methods to reduce amount of intracellular androgens without reducing the circulating testosterone levels.
- Androgen Suppression Strategies for Prostate Cancer: Is There an Ideal Approach?
Current Urology Reports
Volume 12, Issue 3 , pp 188-196
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Androgen suppression therapy
- Hormonal therapy
- Prostate cancer
- Luteinizing hormone–releasing hormone
- LHRH agonists
- LHRH antagonists
- Intermittent hormonal therapy
- Industry Sectors
- Author Affiliations
- 1. Department of Urology, Wilmington VA Medical Center, 1601 Kirkwood Highway, Wilmington, DE, 19805, USA
- 2. Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Suite 1112, Philadelphia, PA, 19107, USA