Current Urology Reports

, Volume 12, Issue 1, pp 47–55

Impact of Genetics on the Diagnosis and Treatment of Renal Cancer

  • Eric A. Singer
  • Gennady Bratslavsky
  • Lindsay Middelton
  • Ramaprasad Srinivasan
  • W. Marston Linehan
Article

DOI: 10.1007/s11934-010-0156-y

Cite this article as:
Singer, E.A., Bratslavsky, G., Middelton, L. et al. Curr Urol Rep (2011) 12: 47. doi:10.1007/s11934-010-0156-y
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Abstract

Kidney cancer is a heterogeneous disease comprised of a number of histologic subtypes, each associated with unique genetic mutations, clinical features, and sensitivity to treatment. By examining families affected with the hereditary kidney cancer syndromes von Hippel-Lindau, hereditary papillary renal cell carcinoma, hereditary leiomyomatosis and renal cell carcinoma, and Birt-Hogg-Dubé, researchers have been able to identify the genes responsible for these syndromes. This work has revealed that kidney cancer is fundamentally a metabolic disorder, and as such, novel targeted therapies specific to their molecular biology have been developed and employed in both the hereditary and sporadic forms of renal cell carcinoma.

Keywords

Kidney cancerGeneticsvon Hippel-LindauVHLHereditary papillary renal carcinomaHPRCHereditary leiomyomatosis and renal cell carcinomaHLRCCBirt-Hogg-Dube’BHDClear cellPapillaryChromophobe

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2010

Authors and Affiliations

  • Eric A. Singer
    • 1
  • Gennady Bratslavsky
    • 1
  • Lindsay Middelton
    • 1
  • Ramaprasad Srinivasan
    • 1
  • W. Marston Linehan
    • 1
  1. 1.Department of Health and Human Services, Urologic Oncology Branch, Center for Cancer Research, National Cancer InstituteNational Institutes of HealthBethesdaUSA