Current Urology Reports

, Volume 7, Issue 3, pp 181–185

Prostate cancer detection strategies

  • Timothy C. Brand
  • Javier Hernandez
  • Edith D. Canby-Hagino
  • Joseph W. Basler
  • Ian M. Thompson
Article

DOI: 10.1007/s11934-006-0019-8

Cite this article as:
Brand, T.C., Hernandez, J., Canby-Hagino, E.D. et al. Curr Urol Rep (2006) 7: 181. doi:10.1007/s11934-006-0019-8

Abstract

Prostate cancer is the most common malignancy in men and, as a result, there has been a nationwide emphasis on screening and detection. With the widespread use of the prostate-specific antigen (PSA), prostate cancer screening effectively detects localized prostate cancer. However, recent reports have identified a significant proportion of prostate cancer in men with low PSA levels. Many of these cancers are higher-grade malignancies. Consequently, PSA may function more effectively as a screening tool when applied over a continuum that is associated with degree of risk, rather than a binary measure. Other markers are currently being investigated. Ideally, a marker will identify the malignancy that is a clinical threat, thereby avoiding intervention for indolent disease. Prevention strategies may be employed for higher-risk patients, and these strategies eventually may be tailored to genetic or other risks.

Copyright information

© Current Science Inc 2006

Authors and Affiliations

  • Timothy C. Brand
    • 1
  • Javier Hernandez
  • Edith D. Canby-Hagino
  • Joseph W. Basler
  • Ian M. Thompson
  1. 1.Department of UrologyUniversity of Texas Health Science CenterSan AntonioUSA