Current Rheumatology Reports

, 16:423

Kawasaki Disease: Pathophysiology, Clinical Manifestations, and Management

  • Victoria R. Dimitriades
  • Amanda G. Brown
  • Abraham Gedalia
VASCULITIS (LR ESPINOZA, SECTION EDITOR)

DOI: 10.1007/s11926-014-0423-x

Cite this article as:
Dimitriades, V.R., Brown, A.G. & Gedalia, A. Curr Rheumatol Rep (2014) 16: 423. doi:10.1007/s11926-014-0423-x
Part of the following topical collections:
  1. Topical Collection on Vasculitis

Abstract

Kawasaki Disease, a systemic vasculitis of unknown origin with specific predilection for the coronary arteries, is the most common cause of childhood-acquired heart disease in western countries. Despite its world-wide incidence, the pathophysiology of this enigmatic disease is still under investigation. Diagnosis is made on a clinical basis, with supportive laboratory evidence and imaging. Once identified, timely initiation of treatment is imperative in order to quell the inflammatory response and decrease the incidence of long-term sequelae, specifically coronary artery aneurysms. Finally, longitudinal follow-up should be implemented based on risk stratification and individualized to each patient.

Keywords

Kawasaki diseaseCoronary arteryAneurysmVasculitisImmunoglobulinCorticosteroidsIVIg resistancePathophysiologyClinical manifestationsManagementTreatmentEtiologyDiagnosis

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Victoria R. Dimitriades
    • 1
  • Amanda G. Brown
    • 1
  • Abraham Gedalia
    • 1
    • 2
  1. 1.Division of Pediatric Rheumatology, Departments of PediatricsLSU Health Sciences Center and Children’s HospitalNew OrleansUSA
  2. 2.Department of Pediatrics/RheumatologyChildren’s HospitalNew OrleansUSA