Current Rheumatology Reports

, 16:407

The Microbiome and Psoriatic Arthritis

Authors

  • Hester Eppinga
    • Department of DermatologyErasmus MC-University Medical Center Rotterdam
  • Sergey R. Konstantinov
    • Department of Gastroenterology and HepatologyErasmus MC-University Medical Center Rotterdam
  • Maikel P. Peppelenbosch
    • Department of Gastroenterology and HepatologyErasmus MC-University Medical Center Rotterdam
    • Department of DermatologyErasmus MC-University Medical Center Rotterdam
PSORIATIC ARTHRITIS (O FITZGERALD AND P HELLIWELL, SECTION EDITORS)

DOI: 10.1007/s11926-013-0407-2

Cite this article as:
Eppinga, H., Konstantinov, S.R., Peppelenbosch, M.P. et al. Curr Rheumatol Rep (2014) 16: 407. doi:10.1007/s11926-013-0407-2
Part of the following topical collections:
  1. Topical Collection on Psoriatic Arthritis

Abstract

Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce inflammatory disease in individuals with underlying genetic susceptibility. The microbiome is a subject of increasing interest in the etiology of these inflammatory immune-mediated diseases. The intestinal microbiome is able to affect extra-intestinal distant sites, including the joints, through immunomodulation. At this point, evidence regarding a relationship between the microbiome and psoriatic arthritis is scarce. However, we hypothesize that common immune-mediated inflammatory pathways seen in the “skin–joint–gut axis” in psoriatic arthritis are induced or at least mediated by the microbiome. Th17 has a crucial function in this mechanism. Further establishment of this connection may lead to novel therapeutic approaches for psoriatic arthritis.

Keywords

MicrobiomeMicrobiotaMycobiomePsoriatic arthritisPsoriasisSpondyloarthritisAutoimmunity

Copyright information

© Springer Science+Business Media New York 2014