Current Rheumatology Reports

, 15:361

Chondroitin and Glucosamine in the Management of Osteoarthritis: An Update


DOI: 10.1007/s11926-013-0361-z

Cite this article as:
Henrotin, Y. & Lambert, C. Curr Rheumatol Rep (2013) 15: 361. doi:10.1007/s11926-013-0361-z
Part of the following topical collections:
  1. Topical Collection on Complementary and Alternative Medicine


The objective of osteoarthritis (OA) treatment is not only control of symptoms (i.e. reducing pain and improving function) but also to preserve joint structure and maintain quality of life. OA management remains challenging. Glucosamine and chondroitin are two compounds available for treatment of OA patients. Taken alone or in combination, they have a good safety profile and a variety of effects. In-vitro and in-vivo experiments have revealed that both compounds induced key intermediates in the OA pathophysiological process. Clinical trials, although providing conflicting and questionable results, report symptomatic and structure-modifying effects for both pharmaceutical-grade compounds. This review will discuss all these subjects and emphasize the importance of the quality of tested compounds for achieving high quality clinical trials.


Osteoarthritis Cartilage Chondroitin sulfate Glucosamine Treatment Complementary and alternative medicine Animal studies Clinical efficacy 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Bone and Cartilage Research Unit, Institute of Pathology, Level 5, CHU Sart-TilmanUniversity of LiègeLiègeBelgium