Current Rheumatology Reports

, Volume 13, Issue 1, pp 90–95

New Insights into the Biology and Pathobiology of Beta2-Glycoprotein I

Authors

  • Bill Giannakopoulos
    • Department of Immunology, Allergy, and Infectious Diseases, St. George Public HospitalUniversity of New South Wales
    • Department of Medicine, St. George Public HospitalUniversity of New South Wales
    • Department of Rheumatology, St. George Public HospitalUniversity of New South Wales
  • Peyman Mirarabshahi
    • Department of Immunology, Allergy, and Infectious Diseases, St. George Public HospitalUniversity of New South Wales
    • Department of Immunology, Allergy, and Infectious Diseases, St. George Public HospitalUniversity of New South Wales
Article

DOI: 10.1007/s11926-010-0151-9

Cite this article as:
Giannakopoulos, B., Mirarabshahi, P. & Krilis, S.A. Curr Rheumatol Rep (2011) 13: 90. doi:10.1007/s11926-010-0151-9

Abstract

β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms by which anti-β2GPI antibodies in complex with β2GPI may predispose an individual to the antiphospholipid syndrome clinical phenotype. This review examines some of the latest novel findings in this area.

Keywords

Beta2-glycoprotein IPhysiologyAutoimmunityAntiphospholipid syndrome

Copyright information

© Springer Science+Business Media, LLC 2010