Current Rheumatology Reports

, Volume 12, Issue 1, pp 40–44

Use of Rituximab in the Antiphospholipid Syndrome

Article

DOI: 10.1007/s11926-009-0074-5

Cite this article as:
Kumar, D. & Roubey, R.A.S. Curr Rheumatol Rep (2010) 12: 40. doi:10.1007/s11926-009-0074-5

Abstract

B cells are promising targets for treatment in autoimmune diseases. Rituximab, a chimeric anti-CD20 monoclonal antibody that depletes B cells, is approved for use in rheumatoid arthritis and is often used to treat refractory autoimmune thrombocytopenia. There is increasing interest in using rituximab in other autoimmune diseases, including the antiphospholipid syndrome. We reviewed the published clinical experience of rituximab use in patients with the antiphospholipid syndrome. Data are limited to case reports and small case series. In 19 of 21 reported cases, rituximab appeared to have a beneficial clinical effect. Antiphospholipid antibodies levels were significantly decreased in ten of 12 cases. Controlled clinical trials are needed to determine if rituximab is effective in the antiphospholipid syndrome.

Keywords

Antiphospholipid Anticardiolipin Lupus anticoagulant Rituximab B cells 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Medicine and Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and ImmunologyThe University of North Carolina at Chapel HillChapel HillUSA