Current Rheumatology Reports

, Volume 9, Issue 1, pp 36–43

Cardiovascular risk, hypertension, and NSAIDs


DOI: 10.1007/s11926-007-0020-3

Cite this article as:
White, W.B. Curr Rheumatol Rep (2007) 9: 36. doi:10.1007/s11926-007-0020-3


During the past 2 years, a great deal of evaluation has been conducted on the cardiovascular (CV) effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors. This review focuses on the effects of the NSAIDs and COX-2 inhibitors on blood pressure and CV events. Clinical trial databases for NSAIDs and COX-2 inhibitors have shown varying levels of destabilization of blood pressure control in treated hypertensive patients as well as variable incident rates of the development of arrhythmias, congestive heart failure, myocardial infarction, and stroke. Nonselective and COX-2 selective NSAIDs can be used carefully in arthritis patients with hypertension and stable CV disorders (excluding congestive heart failure and moderate to severe kidney dysfunction) when the individual clinical benefit of anti-inflammatory therapy outweighs the CV and gastrointestinal risk.

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology CenterUniversity of Connecticut School of MedicineFarmingtonUSA