Current Rheumatology Reports

, Volume 8, Issue 5, pp 386–393

Gene therapy works in animal models of rheumatoid arthritis so what!

  • Fons A. J. van de Loo
  • Jeroen Geurts
  • Wim B. van den Berg

DOI: 10.1007/s11926-006-0070-y

Cite this article as:
van de Loo, F.A.J., Geurts, J. & van den Berg, W.B. Curr Rheumatol Rep (2006) 8: 386. doi:10.1007/s11926-006-0070-y


Rheumatoid arthritis (RA) is a systemic disease with polyarticular manifestation of chronic inflammation in the knees and small joints of hand and feet. The current systemic anti-tumor necrosis factor (TNF)-α therapies with biologics ameliorate disease in 60% to 70% of RA patients. However, biologics must be given systemically in relatively high dosages to achieve constant therapeutic levels in the joints, and side effects have been reported. To this end, local gene delivery can provide an alternative approach to achieve high, long-term expression of biologics, optimizing the therapeutic efficacy and minimizing systemic exposure. Evidence from animal models convincingly supports the application of local gene therapy in rheumatoid arthritis, but preclinical studies remain necessary to evaluate the merge of cell-specific targeting, viral vector development, and disease-regulated transgene expression to optimize efficacy and safety.

Copyright information

© Current Science Inc. 2006

Authors and Affiliations

  • Fons A. J. van de Loo
    • 1
  • Jeroen Geurts
  • Wim B. van den Berg
  1. 1.Rheumatology Research and Advanced Therapeutics, Department of RheumatologyRadboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life SciencesGA, NijmegenThe Netherlands