How can one develop disease-modifying drugs in osteoarthritis?
- Maxime Dougados MD
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A disease-modifying osteoarthritis drug should be able to interfere with the cartilage breakdown observed in this disease. The current question is whether development of a drug should be focused on structural parameters (eg, radiologic joint space width, magnetic resonance imaging cartilage volume, and so on), on clinical parameters such as functional impairment, or on a composite index such as the capacity of the study drug to prevent and/or to retard the requirement for total articular replacement. Another aspect of osteoarthritis trials is that several recent advances have greatly facilitated the conduct of phase I and II studies, such as biological markers of cartilage metabolism and magnetic resonance imaging parameters of cartilage breakdown.
- How can one develop disease-modifying drugs in osteoarthritis?
Current Rheumatology Reports
Volume 7, Issue 1 , pp 22-28
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- 1. René Descartes University, Cochin Hospital, 27 rue du Faubourg, 75014, Saint Jacques, Paris, France