Current Rheumatology Reports

, Volume 7, Issue 1, pp 22–28

How can one develop disease-modifying drugs in osteoarthritis?

  • Maxime Dougados

DOI: 10.1007/s11926-005-0005-z

Cite this article as:
Dougados, M. Curr Rheumatol Rep (2005) 7: 22. doi:10.1007/s11926-005-0005-z


A disease-modifying osteoarthritis drug should be able to interfere with the cartilage breakdown observed in this disease. The current question is whether development of a drug should be focused on structural parameters (eg, radiologic joint space width, magnetic resonance imaging cartilage volume, and so on), on clinical parameters such as functional impairment, or on a composite index such as the capacity of the study drug to prevent and/or to retard the requirement for total articular replacement. Another aspect of osteoarthritis trials is that several recent advances have greatly facilitated the conduct of phase I and II studies, such as biological markers of cartilage metabolism and magnetic resonance imaging parameters of cartilage breakdown.

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Maxime Dougados
    • 1
  1. 1.René Descartes University, Cochin HospitalSaint JacquesFrance

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