Sleep Disorders (RM Benca, Section Editor)

Current Psychiatry Reports

, 15:404

First online:

Depression and Insomnia in Cancer: Prevalence, Risk Factors, and Effects on Cancer Outcomes

  • Michael R. IrwinAffiliated withCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Gefffen School of Medicine, University of California, Los Angeles Email author 

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Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. Behavioral comorbidities often arise during treatment and persist long term to complicate survival and reduce quality of life. This review focuses on depression and insomnia with an emphasis on understanding the role of cancer-specific factors and their contribution to the prevalence of these behavioral comorbidities in cancer patients following cancer diagnosis and treatment. The clinical significance of depression and insomnia for cancer patients is further stressed by epidemiological observations that link depression and insomnia to cancer morbidity and mortality risk.


Depression Insomnia Cancer Sleep disturbance Inflammation Fatigue Anxiety Depressive symptoms Major depression Psychiatry