Altered Brain Reward Circuits in Eating Disorders: Chicken or Egg?
- Guido K. W. FrankAffiliated withDepartments of Psychiatry and Neuroscience, University of Colorado Anschutz Medical Campus, School of Medicine Email author
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The eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) are severe psychiatric disorders with high mortality. Our knowledge about the neurobiology of eating disorders is very limited, and the question remains whether alterations in brain structure or function in eating disorders are state related, remnants of the illness or premorbid traits. The brain reward system is a relatively well-characterized brain circuitry that plays a central role in the drive to eat and individuals with current or past eating disorders showed alterations in those pathways compared to controls. Here we propose that structural and functional alterations in the insula and frontal cortex, including orbitofrontal and cingulate regions, areas that contribute to reward and anxiety processing, could predispose to developing an eating disorder and that adaptive changes in those circuits in response to malnutrition or repeated binge eating and purging could further promote illness behavior, hinder recovery and contribute to relapse.
KeywordsEating disorders ED Anorexia nervosa AN Bulimia nervosa BN Brain imaging Reward Anxiety Circuitry State Trait Dopamine DSM-5 Psychiatry
- Altered Brain Reward Circuits in Eating Disorders: Chicken or Egg?
Current Psychiatry Reports
- Online Date
- August 2013
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Eating disorders
- Anorexia nervosa
- Bulimia nervosa
- Brain imaging
- Industry Sectors
- Author Affiliations
- 1. Departments of Psychiatry and Neuroscience, University of Colorado Anschutz Medical Campus, School of Medicine, Children’s Hospital Colorado, Gary Pavilion A036/B-130 13123 East 16th Avenue, Aurora, CO, 80045, USA