Current Psychiatry Reports

, Volume 14, Issue 4, pp 280–288

Depression and Cognitive Impairment in Older Adults

  • Sara L. Weisenbach
  • Laurie A. Boore
  • Helen C. Kales
Geriatric Disorders (DC Steffens, Section Editor)

DOI: 10.1007/s11920-012-0278-7

Cite this article as:
Weisenbach, S.L., Boore, L.A. & Kales, H.C. Curr Psychiatry Rep (2012) 14: 280. doi:10.1007/s11920-012-0278-7

Abstract

Late life depression (LLD) is a heterogeneous illness with high rates of treatment resistance. Cognitive impairment is common in the context of LLD, and LLD may be a prodromal symptom and/or potentially a risk factor for dementia. This manuscript reviews the most recent research into the cognitive deficits associated with LLD and risk of conversion to dementia in the context of LLD. We discuss potential moderators and mediators of cognitive deficits in LLD, including demographic and clinical variables, in addition to brain structure and function. Potential interventions for cognitive symptoms of LLD are reviewed. We conclude with a discussion of the broader implications of what is now known about LLD, and how this might be applied toward improved prognosis and models for effective treatment.

Keywords

Late life depressionLLDElderlyCognitionDementiaNeuropsychological abnormalitiesMechanisms of cognitive deficitsInterventions for cognitive impairmentTreatment resistance

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Sara L. Weisenbach
    • 1
    • 3
  • Laurie A. Boore
    • 2
  • Helen C. Kales
    • 2
    • 3
    • 4
  1. 1.Department of PsychiatryUniversity of Michigan Medical SchoolAnn ArborUSA
  2. 2.Department of PsychiatryUniversity of Michigan Medical SchoolAnn ArborUSA
  3. 3.Geriatric Research, Education, and Clinical CenterVA Ann Arbor Healthcare SystemAnn ArborUSA
  4. 4.Center for Clinical Management ResearchVA Ann Arbor Healthcare SystemAnn ArborUSA