, Volume 13, Issue 6, pp 434-436
Date: 29 Sep 2011

Combined Antidepressant Strategies Are Not More Effective Than Vigorous Escitalopram Monotherapy: Results of the CO-MED Study

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Trial: Rush AJ, Trivedi MH, Stewart JW, et al.: Combining Medications to Enhance Depression Outcomes (CO-MED): acute and long-term outcomes of a single-blind randomized study. Am J Psychiatry 2011; 168:689–701.

Rating: ••Of major importance.

Keywords: Major depressive disorder . MDD . Depression .Randomized controlled trial . RCT . Antidepressants .Combination therapy . Monotherapy . Escitalopram . Bupropion . Venlafaxine . Mirtazapine . STAR*D . Depression Treatment Network

Introduction: Although many effective medications for depression are available, no treatment is likely to be effective for more than 50% to 60% of the depressed patients who begin therapy with that medication. For example, in the report summarizing outcomes from the first level of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, which evaluated outcomes of more than 2,700 outpatients with major depressive disorder drawn from a nationally representative network of participating primary care an ...