, Volume 13, Issue 2, pp 77-79
Date: 01 Feb 2011

Aripiprazole to Treat Irritability Associated With Autism: A Placebo-Controlled, Fixed-Dose Trial

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Trial: Marcus RN, Owen R, Kamen L, et al.: A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. J Am Acad Child Adolesc Psychiatry 2009, 48:1110–1119.

Rating: •Of importance.

Introduction: Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by qualitative impairments in areas of social interaction and communication, and restrictive, repetitive behaviors [1]. Symptoms typically present prior to 3 years of age and are chronic and impairing. ASDs are not uncommon, with prevalence estimates suggesting rates as high as 2.2 for every 1,000 children [2]. However, early identification and intervention can significantly improve outcomes [3]. In addition to the developmental deficits present with these disorders, serious behavioral disturbances have been associated with ASDs, with irritability being reported in as many as 20% of children affected [4]. Irritability, frequently demonstrated ...