Neurocognitive and Neuroimaging Predictors of Clinical Outcome in Bipolar Disorder
- Carrie E. BeardenAffiliated withDepartment of Psychiatry and Biobehavioral Sciences, UCLADepartment of Psychology, UCLA
- , Michelle WoogenAffiliated withOlin Neuropsychiatric Research Center, Institute of Living
- , David C. GlahnAffiliated withOlin Neuropsychiatric Research Center, Institute of LivingDepartment of Psychiatry, Yale University School of Medicine Email author
Historically, bipolar disorder has been conceptualized as a disease involving episodic rather than chronic dysfunction. However, increasing evidence indicates that bipolar disorder is associated with substantial inter-episode psychosocial and vocational impairment. Here we review the contributions of neurocognitive deficits and structural and functional neuroanatomic alterations to the observed functional impairments. In particular, compelling evidence now suggests that neurocognitive impairments, particularly in the areas of attention, processing speed, and memory, are associated with functional outcome. Although investigation of the neural correlates of functional disability in bipolar disorder is only in its nascent stages, preliminary evidence suggests that white matter abnormalities may be predictive of poor outcome. A better understanding of the relationship between neurocognitive and neuroimaging assays and functional outcome has the potential to improve current treatment options and provide targets for new treatment strategies in bipolar disorder.
KeywordsBipolar disorder Neuropsychology Neuroanatomy Functional neuroimaging Outcome Disability
- Neurocognitive and Neuroimaging Predictors of Clinical Outcome in Bipolar Disorder
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Current Psychiatry Reports
Volume 12, Issue 6 , pp 499-504
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- Current Science Inc.
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- Bipolar disorder
- Functional neuroimaging
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- Author Affiliations
- 1. Department of Psychiatry and Biobehavioral Sciences, UCLA, 300 Medical Plaza, Suite 2265, Los Angeles, CA, 90095, USA
- 2. Department of Psychology, UCLA, 300 Medical Plaza, Suite 2265, Los Angeles, CA, 90095, USA
- 3. Olin Neuropsychiatric Research Center, Institute of Living, Whitehall Research Building, 200 Retreat Avenue, Hartford, CT, 06106, USA
- 4. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA