Current Psychiatry Reports

, Volume 12, Issue 3, pp 255–264

The Impact of Depression in Heart Disease

  • Yelizaveta Sher
  • Sermsak Lolak
  • José R. Maldonado

DOI: 10.1007/s11920-010-0116-8

Cite this article as:
Sher, Y., Lolak, S. & Maldonado, J.R. Curr Psychiatry Rep (2010) 12: 255. doi:10.1007/s11920-010-0116-8


Depression and heart disease affect millions of people worldwide. Studies have shown that depression is a significant risk factor for new heart disease and that it increases morbidity and mortality in established heart disease. Many hypothesized and studied mechanisms have linked depression and heart disease, including serotonergic pathway and platelet dysfunction, inflammation, autonomic nervous system and hypothalamic-pituitary-adrenal axis imbalance, and psychosocial factors. Although the treatment of depression in cardiac patients has been shown to be safe and modestly efficacious, it has yet to translate into reduced cardiovascular morbidity and mortality. Understanding the impact and mechanisms behind the association of depression and heart disease may allow for the development of treatments aimed at altering the devastating consequences caused by these comorbid illnesses.


Depression Heart disease Myocardial infarction Congestive heart failure 

Clinical Trial Acronyms


Atrial Fibrillation and Congestive Heart Failure


Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy


Enhancing Recovery in Coronary Heart Disease Patients


Epidemiological Study of Acute Coronary Syndromes and the Pathophysiology of Emotions


Montreal Heart Attack Readjustment Trial


Myocardial Infarction and Depression–Intervention Trial


Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure


Sertraline Antidepressant Heart Attack Randomized Trial

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Yelizaveta Sher
    • 1
  • Sermsak Lolak
    • 1
  • José R. Maldonado
    • 1
  1. 1.Department of Psychiatry and Behavioral SciencesStanford University Medical CenterStanfordUSA

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