Current Psychiatry Reports

, Volume 12, Issue 2, pp 88-95

First online:

From TADS and SOFTADS to TORDIA and Beyond: What’s New in the Treatment of Adolescent Depression?

  • Zheya Jenny YuAffiliated withHall-Mercer MH/MR Center, Pennsylvania Hospital, University of Pennsylvania Health System
  • , Christopher J. KratochvilAffiliated withUniversity of Nebraska Medical Center Email author 
  • , Ronald A. WellerAffiliated withDepartment of Psychiatry, University of Pennsylvania
  • , Mira MoorevilleAffiliated withUniversity of Michigan
  • , Elizabeth B. WellerAffiliated withThe Children’s Hospital of Philadelphia, University of Pennsylvania

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Major depressive disorder in adolescents is associated with significant morbidity and mortality. Major advances have been made in recent years in the treatment of adolescent depression, with promising outcomes. However, limitations of currently available treatments have prompted attempts to better understand pediatric depression from a broader perspective and to develop more effective treatment strategies in the future.


Adolescent Depression Pharmacotherapy Cognitive-behavioral therapy