Current Psychiatry Reports

, Volume 7, Issue 6, pp 435–440

Update on augmentation of antidepressant response in resistant depression

  • Charles DeBattista
  • Anna Lembke

DOI: 10.1007/s11920-005-0064-x

Cite this article as:
DeBattista, C. & Lembke, A. Curr Psychiatry Rep (2005) 7: 435. doi:10.1007/s11920-005-0064-x


Most patients in acute depression trials fail to achieve remission with antidepressant monotherapy. Many patients seem to require more than one medication to achieve remission or adequate response. Augmentation strategies are commonly used in clinical practice, but most have been poorly studied. In addition, better-studied strategies, such as the use of lithium and thyroid augmentation, have not been well investigated in combination with newer antidepressants. Various novel strategies are being investigated as augmenting agents, including selective dopamine agonists, sex steroids, norepinephrine reuptake inhibitors, glucocorticoid-specific agents, and newer anticonvulsants. We review the status of augmentation strategies in the treatment of depression.

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Charles DeBattista
    • 1
  • Anna Lembke
  1. 1.Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA

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