Current Prostate Reports

, Volume 6, Issue 4, pp 149–154

Androgen deprivation therapy and risk for diabetes and cardiovascular disease in prostate cancer survivors


DOI: 10.1007/s11918-008-0023-1

Cite this article as:
Smith, M.R. Curr prostate rep (2008) 6: 149. doi:10.1007/s11918-008-0023-1


Gonadotropin-releasing hormone (GnRH) agonists are the mainstay of treatment for recurrent and metastatic prostate cancer. GnRH agonists are also an important part of therapy for many men with localized or locally advanced prostate cancer. Although GnRH agonists improve survival in certain settings, they involve adverse effects including vasomotor flushing, obesity, and osteoporosis. This article describes the evidence that GnRH agonists increase risk for diabetes and cardiovascular disease and reviews the potential mechanisms for treatment-related morbidity.

Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.Yawkey Center 7038Massachusetts General Hospital Cancer CenterBostonUSA