Psychiatric Comorbidity of Chronic Daily Headache: Focus on Traumatic Experiences in Childhood, Post-Traumatic Stress Disorder and Suicidality

Chronic Daily Headache (SJ Wang, Section Editor)

DOI: 10.1007/s11916-014-0405-8

Cite this article as:
Juang, K.D. & Yang, CY. Curr Pain Headache Rep (2014) 18: 405. doi:10.1007/s11916-014-0405-8
Part of the following topical collections:
  1. Topical Collection on Chronic Daily Headache


The fifth edition of the Diagnostic and Statistic Manual (DSM-5) reclassified some mental disorders recently. Post-traumatic stress disorder (PTSD) is in a new section termed “trauma- and stressor-related disorder”. Community-based studies have shown that PTSD is associated with a notably high suicidal risk. In addition to previous findings of comorbidity between chronic daily headache (CDH) and both depressive disorders and anxiety disorders, recent data suggest that frequency of childhood maltreatment, PTSD, and suicidality are also increased in CDH. CDH patients with migraine aura are especially at risk of suicidal ideation. Research suggests that migraine attack, aura, frequency, and chronicity may all be related to serotonergic dysfunction. Vulnerability to PTSD and suicidality are also linked to brain serotonin function, including polymorphisms in the serotonin transporter gene (5-HTTLPR). In the present review, we focus on recent advances in knowledge of traumatic experiences in childhood, PTSD, and suicidality in relation to migraine and CDH. We hypothesize that vulnerability to PTSD is associated with migraine attack, migraine aura, and CDH. We further postulate that these associations may explain some of the elevated suicidal risks among patients with migraine, migraine aura, and/or CDH. Field studies are required to support these hypotheses.


Chronic daily headache Psychiatric comorbidity Traumatic experiences in childhood Post-traumatic stress disorder Suicidality 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of PsychiatryTaichung Veterans General HospitalTaichungTaiwan
  2. 2.School of MedicineNational Yang Ming UniversityTaipeiTaiwan
  3. 3.Division of PsychiatryTon Yen General HospitalHsinchuTaiwan

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