Why Do Migraines Often Decrease As We Age?

Migraine (R Cowan, Section Editor)

DOI: 10.1007/s11916-013-0366-3

Cite this article as:
Freitag, F.G. Curr Pain Headache Rep (2013) 17: 366. doi:10.1007/s11916-013-0366-3
Part of the following topical collections:
  1. Topical Collection on Migraine


Migraine undergoes both an evolving state in the formative years but also has a remitting state which bears resemblance to the former. Underlying genetics may contribute to the initiating sequence for these processes but the patient’s lifetime environment may influence the expression of the disease. Systems rarely thought of in terms of neurologic disease such as the inflammatory system may have significant contributions to modulating this process and accounting for the clinical presentation of migraine.


White Matter HyperintensitiesVasodilatory CapacitanceEndotheliumMicrogliaImmunocompetentSpreading DepressionNeurogenic InflammationOxidative StressFerritin

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of NeurologyMedical College of WisconsinMilwaukeeUSA