, Volume 16, Issue 2, pp 180-184
Date: 01 Mar 2012

Oral Triptans in the Preventive Management of Cluster Headache

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Cluster headache is a rare primary neurovascular headache and a severe pain condition with unilateral headache over 15–180 minutes and concomitant unilateral autonomic symptoms. The detailed pathophysiology of the condition is still unclear. Only a few evidence-based therapeutic options for acute therapy and the preventive management of the disease are available. Triptans, in particular sumatriptan 6 mg subcutaneously, are highly effective for acute treatment. This review focuses on the potential use of oral triptans in the prophylaxis of cluster headache.