Allodynia in Cluster Headache
- Avi Ashkenazi
- … show all 1 hide
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Cutaneous allodynia (CA), the perception of pain when a non-noxious stimulus is applied to normal skin, has been described in various pain syndromes. The pathophysiology of CA in headache is thought to be related to central sensitization of brainstem, and possibly thalamic, neurons. The recognition of CA in cluster headache (CH) is recent, and available data are scant. Some studies suggest the occurrence of CA in a significant proportion of CH patients. However, one study that examined sensory thresholds in CH failed to confirm this. CA in CH is characterized by rapid onset and termination, suggesting different mechanisms compared with CA in migraine. CA in CH is common in trigeminal areas but may spread to cervical dermatomes and beyond. The relations between the type of CH (episodic vs chronic) and CA are unknown. Further studies are needed to determine the mechanism of CA in CH, and its clinical implications.
- Meyer RA, Ringkamp M, Campbell JN, Raja CS: Peripheral mechanisms of cutaneous nociception. In Wall and Melzack’s Textbook of Pain, edn 5. Edited by McMahon SB, Koltzenberg M. Elsevier; 2006:3–34.
- Burstein R, Yarnitsky D, Goor-Aryeh I, et al.: An association between migraine and cutaneous allodynia. Ann Neurol 2000, 47:614–624. CrossRef
- LoPinto C, Young WB, Ashkenazi A: Comparison of dynamic (brush) and static (pressure) mechanical allodynia in migraine. Cephalalgia 2006, 26:852–856. CrossRef
- Selby G, Lance JW: Observations on 500 cases of migraine and allied vascular headache. J Neurol Neurosurg Psychiatry 1960, 23:23–32. CrossRef
- Burstein R, Cutrer MF, Yarnitsky D: The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain 2000, 123:1703–1709. CrossRef
- Burstein R, Collins B, Jakubowski M: Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Ann Neurol 2004, 55:19–26. CrossRef
- Lipton RB, Bigal ME, Ashina S, et al.: Cutaneous allodynia in the migraine population. Ann Neurol 2008, 63:148–158. CrossRef
- Ashkenazi A, Sholtzow M, Shaw JW, et al.: Identifying cutaneous allodynia in chronic migraine using a practical clinical method. Cephalalgia 2007, 27:111–117. CrossRef
- Burstein R, Jakubowski M: Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol 2004, 55:27–36. CrossRef
- Dahlof C: Cutaneous allodynia and migraine: another view. Curr Pain Headache Rep 2006, 10:231–238. CrossRef
- May A: Cluster headache: pathogenesis, diagnosis, and management. Lancet 2005, 366:843–855. CrossRef
- May A, Bahra A, Buchel C, et al.: Hypothalamic activation in cluster headache attacks. Lancet 1998, 352:275–278. CrossRef
- Ashkenazi A, Young WB: Dynamic mechanical (brush) allodynia in cluster headache. Headache 2004, 44:1010–1012. CrossRef
- Young WB, Richardson ES, Shukla P: Brush allodynia in hospitalized headache patients. Headache 2005, 45:999–1003. CrossRef
- Ladda J, Straube A, Forderreuther S, et al.: Quantitative sensory testing in cluster headache: increased sensory thresholds. Cephalalgia 2006, 26:1043–1050. CrossRef
- • Marmura MJ, Abbas M, Ashkenazi A: Dynamic mechanical (brush) allodynia in cluster headache: a prevalence study in a tertiary headache clinic. J Headache Pain 2009, 10:255–258. This is the largest study to date on the prevalence of cutaneous allodynia in cluster headache. CrossRef
- Riederer F, Selekler HM, Sandor PS, Wober C: Cutaneous allodynia during cluster headache attacks. Cephalalgia 2009, 29:796–798. CrossRef
- Huber G, Lampl C: Oxygen therapy influences episodic cluster headache and related cutaneous brush and cold allodynia. Headache 2009, 49:134–136. CrossRef
- Rozen TD, Haynes GV, Saper JR, Sheftell FD: Abrupt onset and termination of cutaneous allodynia (central sensitization) during attacks of SUNCT. Headache 2005, 45:153–155. CrossRef
- Berry JD, Petersen KL: A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. Neurology 2005, 65:444–447. CrossRef
- Ashkenazi A, Yang I, Mushtaq A, Shaw JW: Is phonophobia associated with cutaneous allodynia in migraine? A prospective controlled study [abstract]. Neurology 2007, 68:A182.
- Witting N, Kupers RC, Svensson P, et al.: Experimental brush-evoked allodynia activates posterior parietal cortex. Neurology 2001, 57:1817–1824.
- Lorenz J, Cross DJ, Minoshima S, et al.: A unique representation of heat allodynia in the human brain. Neuron 2002, 35:383–393. CrossRef
- Allodynia in Cluster Headache
Current Pain and Headache Reports
Volume 14, Issue 2 , pp 140-144
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Cluster headache
- Central sensitization
- Industry Sectors
- Avi Ashkenazi (1)
- Author Affiliations
- 1. The Neurologic Group of Bucks/Montgomery County, 800 West State Street, Suite 101, Doylestown, PA, 18901, USA