Cosensitization of pain and psychiatric comorbidity in chronic daily headache
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Chronic migraine occurs in approximately 20% of migraineurs, typically developing over a period of many years. The pathophysiology of this transformation is unknown. However, experts have associated chronic headache with analgesic overuse, physical injury, and psychologic trauma. Research in post-traumatic stress disorder has found that hippocampal sensitivity to stress alters and often amplifies future pain behaviors. Although the most obvious difference between migraine and chronic migraine is the frequency of headaches, this article discusses chronic migraine as a more pervasive neurologic disease in which the patient’s neurologic and psychologic function fails to return to a normal baseline. The sensory and affective components of pain are cosensitized, producing other neurologic and psychologic symptoms during and between episodes of headache. A staging paradigm is suggested that defines patients and assesses their overall neurologic function. The goal of this classification is to identify cosensitization early and pinpoint migraine patients who are at risk of developing chronic migraine.
- Headache Classification Subcommittee of International Headache Society: International classification of headache disorders, edn 2. Cephalalgia 2004, 24:24–151. CrossRef
- Silberstein SD, Lipton RB: Chronic daily headache, including transformed migraine, chronic tension-type headache, and medication over use. In Wolff’s Headache and Other Head Pain. Edited by Silberstein SD, Lipton RB, Dalessio DJ. New York: Oxford University Press; 2001:247–282.
- Menken M, Munsat TL, Toole JF: The global burden of disease study. Arch Neurol 2000, 57:418–420. CrossRef
- Breslau N, Lipton RB, Stewart WF, et al.: Comorbidity of migraine and depression. Neurology 2003, 60:1308–1312.
- Silberstein SD: Shared mechanisms and comorbidities in neurologic and psychiatric disorders. Headache 2001, 41(suppl 1):S11-S17. CrossRef
- Couch JR: Complexities of presentation and pathogenesis of migraine headache. In Treating the Headache Patient. Edited by Cady RK, Fox AW. New York: Marcel Dekker; 1995:15–40.
- Spierings EL, Ranke AH, Schroevers M, Honkoop PC: Chronic daily headache: a time perspective. Headache 2000, 40:306–310. CrossRef
- Lipton RB, Diamond S, Reed ML, et al.: Migraine diagnosis and treatment: results of the American Migraine Study II. Headache 2001, 41:538–545.
- Cady RK, Schreiber CP, Farmer KU: Understanding the patient with migraine: the evolution from episodic headache to chronic neurologic disease. Headache 2004, 44:426–435. This article is the prelude to the present one, which traces the theories concerning the transformation of episodic headache into chronic headaches. CrossRef
- Mathew NT: Migraine transformation and chronic daily headache. In Treating the Headache Patient. Edited by Cady RK, Fox AW. New York: Marcel Dekker; 1995:75–100.
- Tepper SJ, Dodick DW: Debate: analgesic overuse is a cause, not consequence, of chronic daily headache. Headache 2002, 42:543–554. An interesting review of two divergent opinions concerning the role of analgesics in chronic headaches. CrossRef
- Jacox AK, Carr DB, Payne R, et al.: Management of cancer pain. In Pain. Clinical Practice Guideline No. 9 (AHCPR Pub No. 94-0592). Rockville, MD: Agency for Health Care Policy and Research; 1994.
- Blau JN: Adult migraine: the patient observed. In Migraine: Clinical and Research Aspects. Edited by Blau JN. Baltimore: Johns Hopkins University Press; 1987:3–30.
- Wolff HG: Headache and Other Head Pain, edn 2. New York: Oxford University Press; 1963.
- Cady R, Schreiber C, Farmer K, Sheftell F: Primary headaches: a convergence hypothesis. Headache 2002, 42:204–216. Elucidates the common pathophysiology of various headache presentations. CrossRef
- Bolay H, Moskowitz MA: Mechanisms of pain modulation in chronic syndromes. Neurology 2002, 59(suppl 2):S2-S7. Technical presentation of sensory and affective components of pain transmission.
- Burstein R, Yarnitsky D, Goor-Aryeh I, et al.: An association between migraine and cutaneous allodynia. Ann Neurol 2000, 47:614–624. CrossRef
- Lupien SJ, Lepage M: Stress, memory, and the hippocampus. Behav Brain Res 2001, 127:137–158. CrossRef
- Sapolsky R: Why stress is bad for your brain. Science 1996, 273:749–750. CrossRef
- Gould E, Tanapat P, McEwen B, et al.: Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci U S A 1998, 95:3168–3171. CrossRef
- Vogel G: New brain cells prompt new theory of depression. Science 2000b, 290:258–259. CrossRef
- Thorp JA, Jones PG, Knox E, Clark RH: Does antenatal corticosteroid therapy affect birth weight and head circumference? Obstet Gynecol 2002, 99:101–108. CrossRef
- Abad V, Chrousos GP, Reynolds JC, et al.: Glucocorticoid excess during adolescence leads to a major persistent deficit in bone mass and an increase in central body fat. J Bone Miner Res 2001, 16:1879–1885. CrossRef
- Lupien SJ, King S, Meaney MJ, McEwen BS: Child’s stress hormone levels correlate with mother’s socioeconomic status and depressive state. Bio Psych 2000, 48:976–980. CrossRef
- Seligman M: Helplessness: On Depression, Development, and Death. San Francisco: WH Freeman; 1975.
- Sheftell F, Atlas S: Migraine and psychiatric comorbidity: from theory and hypothesis to clinical application. Headache 2002, 42:934–944. CrossRef
- Rome HP, Rome JD: Limbically augmented pain syndrome (LAPS): kindling, corticolimbic sensitization, and the convergence of affective and sensory symptoms in chronic pain disorders. Pain Med 2000, 1:7–23. CrossRef
- Cosensitization of pain and psychiatric comorbidity in chronic daily headache
Current Pain and Headache Reports
Volume 9, Issue 1 , pp 47-52
- Cover Date
- Print ISSN
- Online ISSN
- Current Medicine Group
- Additional Links