Current Osteoporosis Reports

, Volume 12, Issue 4, pp 475–485

Imaging of Site Specific Bone Turnover in Osteoporosis Using Positron Emission Tomography

  • Glen M. Blake
  • Musib Siddique
  • Michelle L. Frost
  • Amelia E. B. Moore
  • Ignac Fogelman
Imaging (T Lang and F Wehrli, Section Editors)

DOI: 10.1007/s11914-014-0231-2

Cite this article as:
Blake, G.M., Siddique, M., Frost, M.L. et al. Curr Osteoporos Rep (2014) 12: 475. doi:10.1007/s11914-014-0231-2

Abstract

The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography (18F-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. 18F-NaF PET provides a novel and noninvasive method of studying site-specific bone formation at the hip and spine, as well as areas of pure cortical or trabecular bone. The technique complements conventional measurements of bone turnover using biochemical markers and bone biopsy as a tool to investigate new treatments for osteoporosis, and holds promise of a future role as an early biomarker of treatment efficacy in clinical trials. This article reviews methods of acquiring and analyzing 18F-NaF PET scan data, and outlines a simplified approach that uses 5-minute static PET scan images combined with venous blood samples to estimate 18F-NaF plasma clearance at multiple sites in the skeleton with a single injection of tracer.

Keywords

18F sodium fluorideBone blood flowBone plasma clearanceMetabolic bone diseaseMolecular imagingOsteoporosisOsteoporosis therapyPositron emission tomographyQuantitative radionuclide imagingRegional bone formationRegional bone turnoverStandardized uptake value

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Glen M. Blake
    • 1
  • Musib Siddique
    • 2
  • Michelle L. Frost
    • 1
  • Amelia E. B. Moore
    • 1
  • Ignac Fogelman
    • 3
  1. 1.Osteoporosis Research UnitKing’s College LondonLondonUK
  2. 2.King’s College London, Clinical PET CentreLondonUK
  3. 3.Nuclear Medicine DepartmentKing’s College LondonLondonUK