Current Osteoporosis Reports

, Volume 12, Issue 1, pp 1–8

Bone and the Innate Immune System

Osteoimmunology (D Novack and G Schett, Section Editors)

DOI: 10.1007/s11914-014-0195-2

Cite this article as:
Charles, J.F. & Nakamura, M.C. Curr Osteoporos Rep (2014) 12: 1. doi:10.1007/s11914-014-0195-2


The immune system and bone are intimately linked with significant physical and functionally related interactions. The innate immune system functions as an immediate response system to initiate protections against local challenges such as pathogens and cellular damage. Bone is a very specific microenvironment, in which infectious attack is less common but repair and regeneration are ongoing and important functions. Thus, in the bone the primary goal of innate immune and bone interactions is to maintain tissue integrity. Innate immune signals are critical for removal of damaged and apoptotic cells and to stimulate normal tissue repair and regeneration. In this review we focus on the innate immune mechanisms that function to regulate bone homeostasis.


Bone Innate immunity Osteoclast Osteomac Osteocyte Apoptosis Autophagy Necroptosis 

Copyright information

© Springer Science+Business Media New York (outside the USA) 2014

Authors and Affiliations

  1. 1.Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of Medicine, Division of RheumatologyUniversity of CaliforniaSan FranciscoUSA
  3. 3.Arthritis/Immunology Section, Veterans Affairs Medical CenterSan FranciscoUSA

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