Current Therapeutics (SL Silverman, Section Editor)

Current Osteoporosis Reports

, Volume 10, Issue 1, pp 48-55

First online:

Osteoporosis After Transplantation

  • Carolina A. Moreira KulakAffiliated withDivision of Endocrinology & Metabolism of Hospital de Clínicas - SEMPR, Federal University of ParanaDepartment of Internal Medicine, Federal University of Parana Email author 
  • , Victoria Z. Cochenski BorbaAffiliated withEndocrinology Division of Hospital de Clinicas, Federal University of Parana Serviço de Endocrinologia e Metabologia HC-UFPR (SEMPR)Department of Internal Medicine, Federal University of Parana
  • , Jaime Kulak JúniorAffiliated withDepartment of Obstetrics & Gynecology, Federal University of Parana
  • , Melani Ribeiro CustódioAffiliated withDepartment of Internal Medicine, Nephrology Division, Universidade de São Paulo

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Abstract

Transplantation is an established therapy for end-stage diseases of kidney, lung, liver, and heart among others. Osteoporosis and fragility fractures are serious complications of organ transplantation, particularly in the first post-transplant year. Many factors contribute to the pathogenesis of osteoporosis following organ transplantation. This review addresses the mechanisms of bone loss that occurs both in the early and late post-transplant periods, including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac, and bone marrow transplantation. Prevention and treatment for osteoporosis in the transplant recipient are also discussed.

Keywords

Secondary osteoporosis Transplantation Immunosuppressive agents Bone loss