Current Osteoporosis Reports

, Volume 9, Issue 2, pp 53–59

Effects of Nutrition and Alcohol Consumption on Bone Loss


DOI: 10.1007/s11914-011-0049-0

Cite this article as:
Ronis, M.J.J., Mercer, K. & Chen, JR. Curr Osteoporos Rep (2011) 9: 53. doi:10.1007/s11914-011-0049-0


It is well established that excessive consumption of high-fat diets results in obesity. However, the consequences of obesity on skeletal development, maturation, and remodeling have been the subject of controversy. New studies suggest that the response of the growing skeleton to mechanical loading is impaired and trabecular bone mass is decreased in obesity and after high-fat feeding. At least in part, this occurs as a direct result of inhibited Wnt signaling and activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) pathways in mesenchymal stem cells by fatty acids. Similar effects on Wnt and PPAR-γ signaling occur after chronic alcohol consumption as the result of oxidative stress and result in inhibited bone formation accompanied by increased bone marrow adiposity. Alcohol-induced oxidative stress as the result of increased NADPH-oxidase activity in bone cells also results in enhanced RANKL-RANK signaling to increase osteoclastogenesis. In contrast, consumption of fruits and legumes such as blueberries and soy increase bone formation. New data suggest that Wnt and bone morphogenetic protein signaling pathways are the molecular targets for bone anabolic factors derived from the diet.


Oxidative stressRedoxWntBone morphogenic proteinPPAR-γReceptor activator of NF-κB ligandEstradiolMesenchymal stem cellObesityNonesterified free fatty acidBerriesFruitSoyEthanol

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Martin J. J. Ronis
    • 1
  • Kelly Mercer
    • 2
  • Jin-Ran Chen
    • 3
  1. 1.Department of Pharmacology & ToxicologyUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Arkansas Children’s Nutrition CenterLittle RockUSA
  3. 3.Department of PediatricsUniversity of Arkansas for Medical SciencesLittle RockUSA