Current Osteoporosis Reports

, 7:118

Bone loss or lost bone: Rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss

  • Mone Zaidi
  • Charles H. Turner
  • Ernesto Canalis
  • Roberto Pacifici
  • Li Sun
  • Jameel Iqbal
  • X. Edward Guo
  • Stuart Silverman
  • Solomon Epstein
  • Clifford J. Rosen
Article

DOI: 10.1007/s11914-009-0021-4

Cite this article as:
Zaidi, M., Turner, C.H., Canalis, E. et al. Curr Osteoporos Rep (2009) 7: 118. doi:10.1007/s11914-009-0021-4

Abstract

Recent reports suggest that bone loss begins during late perimenopause at a dramatic rate, even before estrogen levels plummet. During the ensuing 5 years, there is evidence of the beginnings of microarchitectural deterioration, which impacts bone strength and ultimately enhances its propensity to fracture. The diagnosis of osteoporosis based on T-scores alone, or through stratification for a high fracture risk by FRAX, excludes these women who are rapidly losing bone. Because all antiosteoporosis therapies, in particular bisphosphonates, reduce bone loss, we propose aggressive, likely short-term therapy with a goal to reduce bone loss, stabilize bone density, and prevent microarchitectural deterioration.

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Mone Zaidi
    • 1
  • Charles H. Turner
  • Ernesto Canalis
  • Roberto Pacifici
  • Li Sun
  • Jameel Iqbal
  • X. Edward Guo
  • Stuart Silverman
  • Solomon Epstein
  • Clifford J. Rosen
  1. 1.The Mount Sinai Bone ProgramMount Sinai School of MedicineNew YorkUSA

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