New therapies for osteoporosis: Zoledronic acid, bazedoxifene, and denosumab
- Stuart L. SilvermanAffiliated with Email author
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Intravenous (IV) zoledronic acid, a new once-yearly bisphosphonate therapy, is approved by the US Food and Drug Administration for treatment of postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, and osteoporosis in men. IV zoledronic acid significantly reduced the risk of vertebral, nonvertebral, and hip fractures in postmenopausal women and decreased risk of clinical fracture and clinical vertebral fracture in men and women with hip fracture. Two promising new therapies are in late clinical development. Denosumab is a monoclonal receptor activator of nuclear factor-κB ligand (RANKL) antibody given by subcutaneous injection every 6 months that has been shown to significantly reduce risk of vertebral-, nonvertebral-, and hip fracture in postmenopausal women. Bazedoxifene, an estrogen agonist/antagonist, has significantly reduced the risk of vertebral fracture in postmenopausal women; a post hoc analysis showed reduction in risk of nonvertebral fracture in high-risk women.
- New therapies for osteoporosis: Zoledronic acid, bazedoxifene, and denosumab
Current Osteoporosis Reports
Volume 7, Issue 3 , pp 91-95
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Author Affiliations
- 1. 8641 Wilshire Boulevard, Suite 301, Beverly Hills, CA, 90211, USA